activation-induced cytidine deaminase

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NCBI Description of AICDA

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).

Community Annotation of AICDA Add / Edit AICDA: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


AICDA is highly significantly mutated in
AICDA is significantly mutated in
AICDA is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for AICDA