AICDA Back

activation-induced cytidine deaminase

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NCBI Description of AICDA
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AICDA is highly significantly mutated in
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AICDA is significantly mutated in
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AICDA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for AICDA