AHCY Back

S-adenosylhomocysteine hydrolase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of AHCY

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of AHCY Add / Edit AHCY: Annotations

No community annotations yet for AHCY.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AHCY is highly significantly mutated in
(none)
AHCY is significantly mutated in
(none)
AHCY is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for AHCY