alanine-glyoxylate aminotransferase

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NCBI Description of AGXT

This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


AGXT is highly significantly mutated in
AGXT is significantly mutated in
AGXT is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for AGXT