AGPAT2 Back

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of AGPAT2

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Community Annotation of AGPAT2 Add / Edit AGPAT2: Annotations

No community annotations yet for AGPAT2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AGPAT2 is highly significantly mutated in
(none)
AGPAT2 is significantly mutated in
(none)
AGPAT2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for AGPAT2