AGAP2 Back

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

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NCBI Description of AGAP2

The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of AGAP2 Add / Edit AGAP2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


AGAP2 is highly significantly mutated in
AGAP2 is significantly mutated in
AGAP2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for AGAP2