AFF4 Back

AF4/FMR2 family, member 4

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NCBI Description of AFF4

The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23).

Community Annotation of AFF4 Add / Edit AFF4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AFF4 is highly significantly mutated in
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AFF4 is significantly mutated in
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AFF4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for AFF4