AFF3 Back

AF4/FMR2 family, member 3

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NCBI Description of AFF3
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.

Community Annotation of AFF3 Add / Edit AFF3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AFF3 is highly significantly mutated in
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AFF3 is significantly mutated in
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AFF3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for AFF3