AFF2 Back

AF4/FMR2 family, member 2

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NCBI Description of AFF2
This gene encodes a putative transcriptional activator that is a member of the AF4\\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation. Alternate splicing results in multiple transcript variants.

Community Annotation of AFF2 Add / Edit AFF2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AFF2 is highly significantly mutated in
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AFF2 is significantly mutated in
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AFF2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for AFF2