ADRBK1 Back

adrenergic, beta, receptor kinase 1

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NCBI Description of ADRBK1
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ADRBK1 is highly significantly mutated in
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ADRBK1 is significantly mutated in
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ADRBK1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ADRBK1