ADH1A Back

alcohol dehydrogenase 1A (class I), alpha polypeptide

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ADH1A
This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence.

Community Annotation of ADH1A Add / Edit ADH1A: Annotations

No community annotations yet for ADH1A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ADH1A is highly significantly mutated in
(none)
ADH1A is significantly mutated in
(none)
ADH1A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ADH1A