ADARB1 Back

adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)

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NCBI Description of ADARB1
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ADARB1 is highly significantly mutated in
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ADARB1 is significantly mutated in
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ADARB1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ADARB1