ADAMTS8 Back

ADAM metallopeptidase with thrombospondin type 1 motif, 8

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ADAMTS8
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.

Community Annotation of ADAMTS8 Add / Edit ADAMTS8: Annotations

No community annotations yet for ADAMTS8.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ADAMTS8 is highly significantly mutated in
(none)
ADAMTS8 is significantly mutated in
(none)
ADAMTS8 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ADAMTS8