ADAM metallopeptidase with thrombospondin type 1 motif, 6

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NCBI Description of ADAMTS6

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ADAMTS6 is highly significantly mutated in
ADAMTS6 is significantly mutated in
ADAMTS6 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ADAMTS6