ADAM8 Back

ADAM metallopeptidase domain 8

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ADAM8
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.

Community Annotation of ADAM8 Add / Edit ADAM8: Annotations

No community annotations yet for ADAM8.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ADAM8 is highly significantly mutated in
(none)
ADAM8 is significantly mutated in
(none)
ADAM8 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ADAM8