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ADAM metallopeptidase domain 7

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NCBI Description of ADAM7

This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ADAM7 is highly significantly mutated in
ADAM7 is significantly mutated in
ADAM7 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ADAM7