ADAM2 Back

ADAM metallopeptidase domain 2 (fertilin beta)

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NCBI Description of ADAM2
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ADAM2 is highly significantly mutated in
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ADAM2 is significantly mutated in
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ADAM2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ADAM2