activin A receptor, type IC

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NCBI Description of ACVR1C

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008].

Community Annotation of ACVR1C Add / Edit ACVR1C: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ACVR1C is highly significantly mutated in
ACVR1C is significantly mutated in
ACVR1C is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ACVR1C