ACSS2 Back

acyl-CoA synthetase short-chain family member 2

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NCBI Description of ACSS2

This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.

Community Annotation of ACSS2 Add / Edit ACSS2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ACSS2 is highly significantly mutated in
ACSS2 is significantly mutated in
ACSS2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ACSS2