ACR Back

acrosin

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ACR
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.

Community Annotation of ACR Add / Edit ACR: Annotations

No community annotations yet for ACR.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ACR is highly significantly mutated in
(none)
ACR is significantly mutated in
(none)
ACR is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ACR