ACO1 Back

aconitase 1, soluble

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ACO1

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Community Annotation of ACO1 Add / Edit ACO1: Annotations

No community annotations yet for ACO1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ACO1 is highly significantly mutated in
ACO1 is significantly mutated in
4 patients (3%)
ACO1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ACO1