ACER2 Back

alkaline ceramidase 2

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NCBI Description of ACER2

The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010].

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ACER2 is highly significantly mutated in
ACER2 is significantly mutated in
ACER2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ACER2