ACAN Back

aggrecan

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ACAN
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.

Community Annotation of ACAN Add / Edit ACAN: Annotations

No community annotations yet for ACAN.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ACAN is highly significantly mutated in
(none)
ACAN is significantly mutated in
(none)
ACAN is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ACAN