ACAD8 Back

acyl-Coenzyme A dehydrogenase family, member 8

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NCBI Description of ACAD8
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.

Community Annotation of ACAD8 Add / Edit ACAD8: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ACAD8 is highly significantly mutated in
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ACAD8 is significantly mutated in
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ACAD8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ACAD8