ACACA Back

acetyl-Coenzyme A carboxylase alpha

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ACACA
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Community Annotation of ACACA Add / Edit ACACA: Annotations

No community annotations yet for ACACA.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ACACA is highly significantly mutated in
(none)
ACACA is significantly mutated in
(none)
ACACA is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ACACA