ABL2 Back

v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

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NCBI Description of ABL2
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ABL2 is highly significantly mutated in
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ABL2 is significantly mutated in
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ABL2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ABL2