ABCC9 Back

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ABCC9
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants.

Community Annotation of ABCC9 Add / Edit ABCC9: Annotations

No community annotations yet for ABCC9.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ABCC9 is highly significantly mutated in
(none)
ABCC9 is significantly mutated in
(none)
ABCC9 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ABCC9