ABCC4 Back

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

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NCBI Description of ABCC4
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.

Community Annotation of ABCC4 Add / Edit ABCC4: Annotations

No community annotations yet for ABCC4.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ABCC4 is highly significantly mutated in
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ABCC4 is significantly mutated in
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ABCC4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ABCC4