ABCB8 Back

ATP-binding cassette, sub-family B (MDR/TAP), member 8

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ABCB8

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes.

Community Annotation of ABCB8 Add / Edit ABCB8: Annotations

No community annotations yet for ABCB8.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ABCB8 is highly significantly mutated in
ABCB8 is significantly mutated in
ABCB8 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ABCB8