AATK Back

apoptosis-associated tyrosine kinase

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NCBI Description of AATK
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of AATK Add / Edit AATK: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AATK is highly significantly mutated in
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AATK is significantly mutated in
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AATK is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for AATK