AATF Back

apoptosis antagonizing transcription factor

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of AATF
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.

Community Annotation of AATF Add / Edit AATF: Annotations

No community annotations yet for AATF.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AATF is highly significantly mutated in
(none)
AATF is significantly mutated in
(none)
AATF is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for AATF