aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

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NCBI Description of AASDHPPT

The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


AASDHPPT is highly significantly mutated in
AASDHPPT is significantly mutated in
AASDHPPT is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for AASDHPPT