AARS2 Back

alanyl-tRNA synthetase 2, mitochondrial (putative)

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NCBI Description of AARS2
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AARS2 is highly significantly mutated in
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AARS2 is significantly mutated in
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AARS2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for AARS2