A2ML1 Back

alpha-2-macroglobulin-like 1

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NCBI Description of A2ML1
This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for several proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID: 20805888). Alternative splicing results in multiple transcript variants.

Community Annotation of A2ML1 Add / Edit A2ML1: Annotations

No community annotations yet for A2ML1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

A2ML1 is highly significantly mutated in
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A2ML1 is significantly mutated in
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A2ML1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for A2ML1